kalma 2mg alprazolam

$55.00

Description

kalma 2mg alprazolam

kalma 2mg alprazolam  Active ingredient: Alprazolam an anti-anxiety, benzodiazepine derivative chemically and pharmacologically related to other drugs of this class.

The tablets also contain the following

inactive ingredients:

  • lactose monohydrate
  • sodium benzoate (211)
  • maize starch
  • magnesium stearate
  • sodium starch glycollate
  • microcrystalline cellulose
  • colloidal anhydrous silica
  • povidone
  • docusate sodium
  • indigo carmine CI 73015 (132) (Kalma 0.5 mg and Kalma 1 mg
    only)
  • erythrosine CI 45430 (127) (Kalma 0.5 mg only).
    Kalma also contains sugars (as lactose and benzoates). The tablets are gluten free.

PHARMACEUTICAL FORM

  1. 0.25 mg : alprazolam 0.25 mg tablet: white, oval, marked AL0.25 on one side, G on reverse.
  2. 0.5 mg : alprazolam 0.5 mg tablet: pale pink, oval, marked AL0.5 on one side, G on reverse.
  3. Kalma 1: alprazolam 1 mg tablet: pale blue, oval, marked AL1.0 on one side, G on reverse.
  4. Kalma 2: alprazolam 2 mg tablet: white, oblong, triple scored, marked AL on one side, G2 on reverse.

DOSE AND METHOD OF ADMINISTRATION

The optimum dosage of Kalma should be individualised, based upon the severity of the symptoms and also individual patient response. The daily dosage shown in Table 1 will meet the needs of most patients.

CONTRAINDICATIONS

pills Kalma 2 mg is contraindicated in:

  • Known hypersensitivity to benzodiazepines.
  • Chronic obstructive airways disease with incipient respiratory failure.
  • Myasthenia gravis.

NATURE AND CONTENTS OF CONTAINER

1 Kalma 0.25: Available in bottle packs (HDPE) of 10 and 50 tablets
2 Kalma 0.5: Available in bottle packs (HDPE) of 10 and 50 tablets
3 Kalma 1: Available in bottle packs (HDPE) of 10 and 50 tablets
4 Kalma 2: Available in bottle packs (HDPE) of 50 tablets
Not all strengths and/or pack sizes may be available.

LIST OF EXCIPIENTS

Kalma 0.25, Kalma 0.5, Kalma 1 and Kalma 2 tablets also contain lactose monohydrate, microcrystalline
cellulose, maize starch, sodium benzoate, docusate sodium, povidone, colloidal anhydrous silica, sodium
starch glycollate, magnesium stearate, . Kalma 0.5 tablets also c

PHARMACOKINETIC PROPERTIES

Absorption

Following oral administration to fasting subjects, Alprazolam exhibits linear kinetics; after single dose administration of 0.5 to 3 mg, plasma levels of 8 to 40 nanogram/mL.

In vitro alprazolam is bound (80%) to human serum protein. Serum albumin accounts for the majority of the binding.

Metabolism

Alprazolam extensively metabolised in humans, primarily by cytochrome P450 3A4 (CYP3A4), to two major metabolites in the plasma: 4-hydroxyalprazolam and α-hydroxyalprazolam. A benzophenone derived
from alprazolam is also found in humans.

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